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Summaries of Review for Applications to RFA 06-01

The following is a listing of all applications reviewed under RFA 06-01 for CIRM SEED Grants. Applications are ordered by application number and include the score (between 0 and 100, with 100 being the best) and a funding recommendation (indicated by the color key below) made by the Scientific and Medical Research Funding Working Group (SMRFWG) during the review meeting on November 28-30, 2006. A link to the Public Abstract (provided by applicant), Statement of Benefit to California (provided by applicant), and Public Review Report are available for each application by clicking on the respective application number.

      = Recommended for funding          = Recommended if funds available          = Not Recommended at this time

 

Application Number Title Scientific Score
RS1-00153-1 Control of neural stem-to-progenitor transitions by Cyclin D family members in ES cells 73
RS1-00154-1 Increasing the number and survival of hESC and the derived lineages in tissue culture.  
RS1-00156-1 Designing monitoring systems for beta-cell differentiation from ES cells  
RS1-00157-1 Physiological reactions to tumors in a mouse/hES cell model of brain cancer 77
RS1-00159-1 Modeling leukemia stem cells using human ESC 72
RS1-00160-1 Human embryonic stem cells for repairing stroke injuries in hippocampal slices.  
RS1-00161-1 MicroRNA Regulation of Human Embryonic Stem Cell Self-Renewal and Differentiation 86
RS1-00162-1 In Vitro Differentiation of Human ES cells to Endoderm for Engraftment in Lung  
RS1-00163-1 Programmed Cell Death Pathways Activated in Embryonic Stem Cells 88
RS1-00164-1 Induction of cardiogenesis in human stem cells via chromatin remodeling  
RS1-00165-1 Genome Replacement in Human Embryonic Stem Cells  
RS1-00167-1 Characterization of Immune Responses in Human Embryonic Stem Cells  
RS1-00168-1 Blood formation from human ES cells  
RS1-00169-1 Discovering Potent Molecules with Human ESCs to Treat Heart Disease 81
RS1-00170-1 In vitro differentiation of hESCs into corticospinal motor neurons 83
RS1-00171-1 Development of Neuro-Coupled Human Embryonic Stem Cell-Derived Cardiac Pacemaker Cells. 85
RS1-00172-1 Genetic modification of the human genome to resist HIV-1 infection and/or disease progression 80
RS1-00173-1 Combinatorial Platform for Optimizing Microenvironments to Control hESC Fate 81
RS1-00174-1 A method to maintain and propagate pluripotent human ES cells 85
RS1-00175-1 Assessing efficacy and safety of retro- and lentiviruses as gene therapy vectors in human embryonic stem cells  
RS1-00177-1 Prevalence and functional consequences of chromosomal mosaicism in hESC lines.  
RS1-00178-1 Pharmacological characterization of human stem cells and their differentiation via the GPCR transcriptome  
RS1-00179-1 High efficiency and high fidelity somatic cell nuclear reprogramming  
RS1-00180-1 Retinal Pigment Epithelium Derived From Human Embryonic Stem Cells 74
RS1-00181-1 SEED: Whole Stem Cell Sorting Using an All-Electronic Microfluidic System  
RS1-00182-1 Imaging and Tracking of Stem Cells In Vivo with Magnetic Particle Imaging  
RS1-00183-1 EC regeneration in cerebrovascular ischemia: role of NO 77
RS1-00184-1 Nanotechnology Differentiation of Human Embryonic Stem Cells (hESCs)  
RS1-00185-1 Molecular Markers of Chondrogenesis 75
RS1-00186-1 Developing an Effective Stem Cell Gene Therapy to Treat Human Disease   
RS1-00187-1 Precursors isolated from human embryonic stem cell culture: potential use for kidney regeneration  
RS1-00188-1 DETERMINING THE ROLE OF MITOCHONDRIA IN THE REGULATION OF HUMAN EMBRYONIC STEM CELLS  
RS1-00189-1 Control of embryonic stem cell transcription by TGFb/Smad signaling  
RS1-00190-1 A HUMAN EMBRYONIC STEM CELL MODEL FOR THE DEVELOPMENT OF CD30-POSITIVE HODGKIN LYMPHOMA REED-STERNBERG CELLS (H-RS)  
RS1-00192-1 An Optimal Bioreactor For Production Of Erythrocytes From Human Embryonic Stem Cells  
RS1-00193-1 Retinoic Acid-FGF Antagonism during Motor Neuron Differentiation of Human ES Cells 75
RS1-00195-1 Regulation of Specific Chromosomal Boundary Elements by CTCF Protein Complexes in Human Embryonic Stem Cells 88
RS1-00198-1 Specification of Ventricular Myocyte and Pacemaker Lineages Utilizing Human Embryonic Stem Cells 90
RS1-00199-1 Assessing the role of Eph/ephrin signaling in hESC growth and differentiation 88
RS1-00200-1 Role of Glycans in Human Embryonic Stem Cell Conversion to Neural Precursor Cells 81
RS1-00201-1 Regulation of human embryonic stem cell fate by different forms of the Polycomb transcriptional silencing machinery.  
RS1-00203-1 Genetic Enhancement of the Immune Response to Melanoma via hESC-derived T cells 79
RS1-00205-1 Generation of forebrain neurons from human embryonic stem cells 96
RS1-00207-1 Human Embryonic Stem Cell Differentiation to Trophoblast: Basic Biology and Clinical Translation to Improve Human Fertility 91
RS1-00208-1 Mechanisms of hESC derived MSCs and BMSSCs to regenerate bone tissue  
RS1-00209-1 Development of the Stem Cell Matrix, a Shared Database of Stem Cell Information  
RS1-00210-1 The APOBEC3 Gene Family as Guardians of Genome Stability in Human Embryonic Stem Cells 95
RS1-00211-1 The Use of Microfluidic Chambers and Microtechnology to Study hESC-derived Neural Cells  
RS1-00212-1 Targeting lentiviral vectors to modified hES derived dendritic cells  
RS1-00213-1 Generation of Inherited Disease Human Embryonic Stem Cell Lines  
RS1-00214-1 EFFECTS OF SMALL MOLECULE LIBRARIES ON DIFFERENTIATION OF EMBRYONIC AND NERAL STEMS CELLS IN DOPAMINERGIC PHENOTYPE  
RS1-00215-1 Identifying small molecules that stimulate the differentiation of hESCs into dopamine-producing neurons 87
RS1-00216-1 Metabolomic Signatures of Pluripotent Cell Lines  
RS1-00217-1 Instructive Biomaterials for Stem Cell Differentiation  
RS1-00218-1 Manipulation of Hedgehog signaling in early human embryos  
RS1-00219-1 Alteration of pre-mRNA splicing during stem cell differentiation 73
RS1-00221-1 Elucidating Chemotropic Responses of Human Embryonic Stem Cells to Guidance Cues 71
RS1-00222-1 Therapeutic potential of Retinal Pigment Epithelial cell lines derived from hES cells for retinal degeneration. 81
RS1-00223-1 Identification and Analysis of Genome-wide Intra- and Inter-chromosomal Associations in Human Embryonic Stem Cells  
RS1-00224-1 Genetic analysis and modification of hES cells  
RS1-00225-1 New Chemokine-Derived Therapeutics Targeting Stem Cell Migration 82
RS1-00227-1 Formation of Personalized Embryonic Stem-Like Cells by In Vitro Epigenetic Cell Reprogramming  
RS1-00228-1 Derivation and Characterization of Cancer Stem Cells from Human ES Cells 89
RS1-00229-1 Developing chicken embryos as an experimental microenvironment for human embryonic stem cells  
RS1-00230-1 Brain Aging and hESC-derived Neural Stem Cell Transplantation  
RS1-00232-1 Role of Notch signaling in human embryonic stem cell differentiation to neuronal cell fates 73
RS1-00233-1 Epigenetic regulation of AAVS1  
RS1-00234-1 Therapeutic potential of genetically modified human ES cells in an Alzheimer's disease model: Contribution of IGF-1  
RS1-00236-1 Novel vectors for gene transfer into human ES cells 88
RS1-00237-1 Characterization and Modulation of the Natural Antibody-Mediated Immune Response to Human Embryonic Stem Cells  
RS1-00239-1 Micro Platform for Controlled Cardiac Myocyte Differentiation 77
RS1-00240-1 Analyzing myc function in human embryonic stem cells  
RS1-00241-1 Detection of Cell Lineages Among Stem Cell Progeny by microRNA Profiling  
RS1-00242-1 Technology for hESC-Derived Cardiomyocyte Differentiation and Optimization of Graft-Host Integration in Adult Myocardium 77
RS1-00243-1 Differentiation of Human Embryonic Stem Cells to Intestinal Fates 87
RS1-00245-1 Cellular epigenetic diversity as a blueprint for defining the identity and functional potential of human embryonic stem cells 92
RS1-00246-1 Stem Cell Lipid Organization  
RS1-00247-1 Development of human ES cell lines as a model system for Alzheimer disease drug discovery 71
RS1-00249-1 hESC as tools to investigate the neural crest origin of Ewing's sarcoma 82
RS1-00250-1 The Mammalian Stress Response and Human Embryonic Stem Cell Survival  
RS1-00252-1 Titanium Oxide Nanotube Platforms for Bioartificial Livers and for Transplantation of Hepatocytes Derived from Human Embryonic Stem Cells  
RS1-00253-1 Human embryonic stem cell-derived neurons as a model to discover safer estrogens for hot flashes  
RS1-00254-1 Therapeutic Potential of Transplanted human Embryonic Stem Cells Overexpressing Soluble APP in Treating Alzheimer's Disease  
RS1-00256-1 Therapeutic Potential of Human Embryonic Stem Cells: Cardiovascular Tissue Engineering  
RS1-00258-1 Derivation of Customized Stem Cells for Regenerative Medical Therapy   
RS1-00259-1 Modeling Human Embryonic Development with Human Embryonic Stem Cells 91
RS1-00260-1 Stem Cell Transdifferentiation in the Testis  
RS1-00261-1 Analysis of the Mode of Division of Human Embryonic Stem Cells  
RS1-00262-1 Regulation of human neural progenitor cell proliferation by Ryk-mediated Wnt signaling 78
RS1-00265-1 Isolation of Human Lymphoid Progenitors and Induction to the B and T Cell Fates  
RS1-00266-1 Orthopaedic Applications of Human Embryonic Stem Cells.  
RS1-00267-1 Role of MYC and chromatin regulators in human embryonic stem cells  
RS1-00269-1 Interaction of BMP and polycomb pathways in human ES cell differentiation  
RS1-00270-1 Functional endothelial cells from human embryonic stem cells for therapeutic vasculogenesis  
RS1-00271-1 Optimization of guidance response in human embryonic stem cell derived midbrain dopaminergic neurons in development and disease 90
RS1-00274-1 A novel approach for pancreatic beta-cell differentiation in vitro and in vivo  
RS1-00275-1 Neurogenesis in Alzheimer's Disease: A-beta, Friend or Foe?  
RS1-00276-1 Derivation and characterization of dopamine neurons from human embryonic stem cells  
RS1-00277-1 Comprehensive study of the osteogenic potential of human embryonic stem cells - are they equivalent to liposuctioned fat and bone marrow derived stem cells?  
RS1-00279-1 Chromosome instability due to telomere loss in human embryonic stem cells 74
RS1-00280-1 Generation of long-term cultures of human hematopoietic multipotent progenitors from embryonic stem cells 90
RS1-00281-1 The Role of Ion Channels in the Differentiation of Embryonic Stem Cells  
RS1-00282-1 The Role of NF-kappaB in Human Embryonic Stem Cell Survival and Differentiation  
RS1-00283-1 Trophoblast differentiation of human ES cells. 78
RS1-00287-1 Paracrine factor-mediated stem cell differentiation to cardiac myocytes  
RS1-00288-1 Gene regulatory mechanisms that control spinal neuron differentiation from hES cells. 94
RS1-00289-1 Stem Cell Survival and Differentiation Through Chemical Genetics 85
RS1-00290-1 High Throughput for Small Molecule Probes of hESC Pluriopotency  
RS1-00292-1 Mapping the transcriptional regulatory elements in the genome of hESC 81
RS1-00294-1 Differentiation, Survival, and Function of hESC-Derived Cardiomyocytes  
RS1-00295-1 In Vitro Differentiation of T cells from Human Embryonic Stem Cells. 74
RS1-00296-1 Engineering pluripotent hESC-like cells by genetic reprogramming of differentiating cells  
RS1-00297-1 Isolation of coronary progenitor cells from hESC  
RS1-00298-1 Functions of RB family proteins in human embryonic stem cells 90
RS1-00299-1 Anesthetic Effects on Neural Stem Cells  
RS1-00300-1 Engineering Bioactive Hydrogels for Neuronal Differentiation of hESCs  
RS1-00301-1 NOVEL REAGENTS TO CONTROL STEM CELL DIFFERENTIATION  
RS1-00302-1 A Chemical Approach to Stem Cell Biology 82
RS1-00303-1 Characterization of human embryonic stem cells in vivo in the SCID-hu mouse model.  
RS1-00304-1 Role of Liver-Enriched Transcription Factors in Differentiation of Human ES Cells  
RS1-00305-1 Generation of hESC lines, under defined conditions, modeling normal & diseased states from material stored at the Burnham shared embryo bank. 95
RS1-00308-1 Endodermal differentiation of human ES cells 72
RS1-00309-1 The consequences of chromosome imbalance: using a trisomic human embryonic stem cell line to determine the primary defects in individuals trisomic for chromosome 13 (Patau syndrome)  
RS1-00311-1 Use of small organic molecules to enhance, control, and understand survival and self renewal of human embryonic stem cells in vitro 76
RS1-00312-1 Characterization of factors involved in the regulation of chromatin structure and human stem cell pluripotency  
RS1-00313-1 Role of Mitochondria in Self-Renewal Versus Differentiation of Human Embryonic Stem Cells 90
RS1-00314-1 An Integrated Microfluidic Platform for Screening hESC Culture Conditions 71
RS1-00315-1 Derivation of Human Embryonic Stem Cell-Like Cells from the Testis  
RS1-00317-1 Role of HDAC in human stem cells pluripotentiality and differentiation 79
RS1-00318-1 MOLECULAR MECHANISMS OF CELL MOTILITY IN HUMAN NEURAL STEM CELLS  
RS1-00319-1 Reprogramming Differentiated Human Cells to a Pluripotent State 88
RS1-00321-1 Embryonic stem cell-derived thymic epithelial cells 76
RS1-00322-1 In Vivo Imaging of Human Embryonic Stem Cell Derivatives and Tumorigenicity 85
RS1-00323-1 Role of Chromatin Modifiers in Regulating Human Embryonic Stem Cell Pluripotency 91
RS1-00324-1 Establishment of human Embryonic Stem Cell Models to Study the Impact of Alzheimer's Disease Mutant Genes on Neuronal Functions  
RS1-00326-1 In Vivo Molecular Magnetic Resonance Imaging of Human Embryonic Stem Cells in Murine Model of Myocardial Infarction 91
RS1-00327-1 Self-renewal of human embryonic stem cells 88
RS1-00328-1 Characterization of MicroRNA (miRNA) Functions in Human Embryonic Stem Cells (hESCs)  
RS1-00329-1 Role of Ion Channels in Self-renewal and Fate Decisions of Human Embryonic Stem Cells  
RS1-00331-1 Modeling Parkinson's Disease Using Human Embryonic Stem Cells 82
RS1-00332-1 Human stem cell-derived motor neurons as an experimental model for ALS  
RS1-00333-1 Genetic manipulation of human embryonic stem cells and its application in studying CNS development and repair 81
RS1-00334-1 Human Embryonic Stem Cells and Neural Crest Plasticity  
RS1-00335-1 Reconstruction of Pathways involved in cardiomyocyte differentiation from embryonic stem cells  
RS1-00336-1 Defining Heterogeneity of Human Embryonic Stem Cells  
RS1-00357-1 Establishment of human embryonic stem cell lines using re-constructed human embryos derived from polyspermic eggs  
RS1-00360-1 Micropallet Arrays to Screen and Select Stem Cells 72
RS1-00361-1 Telomerase and self-renewal in human embyronic stem cells  
RS1-00365-1 Profiling surface glycans and glycoprotein expression of human embryonic stem cells 92
RS1-00367-1 Magnetic Resonance Characteristics of CNS Changes Resulting from Targeted Human Embryonic Stem Cell Administration  
RS1-00368-1 A functional assessment of metabolic reconstruction in human embryonic stem cells  
RS1-00371-1 MHC-I suppression for long-term survival of hESC-derived oligodendrocytes and neurons  
RS1-00372-1 Genome-Wide High-Resolution Mapping of DNA Methylation in Human Embryonic Stem Cells  
RS1-00373-1 Generation of beta-cells from hepatocytes  
RS1-00374-1 Reversing age-imposed inhibition of stem cell regenerative potential  
RS1-00376-1 The control of cell movement and invasion in human embryoid bodies.  
RS1-00377-1 The Immunological Niche: Effect of immunosuppressant drugs on stem cell proliferation, gene expression, and differentiation in a model of spinal cord injury. 77
RS1-00378-1 Exploring the Therapeutic Potential of Human Embryonic Stem Cells in Pediatric Neurotrauma  
RS1-00379-1 Cell-Cell Interactions Promote Differentiation of Human Embryonic Stem Cells to Insulin-Secreting Cells  
RS1-00380-1 Ovol genes and hES differentiation into hair-producing cells  
RS1-00381-1 Labeling of human embryonic stem cells with iron oxide nanoparticles and fluorescent dyes for a non-invasive cell depiction with MR imaging and optical imaging 78
RS1-00382-1 Differentiation of Tooth Specific Cells  
RS1-00383-1 HLH Factors in Human Embryonic Stem Cells  
RS1-00384-1 Use of Human Embryonic Stem Cells for the Study of Myelin Regeneration  
RS1-00385-1 Engineering system platforms for human stem cell maintenance and differentiation  
RS1-00387-1 Predifferentiation of human embryonic stem cells for CNS cortical applications 77
RS1-00388-1 New Strategies to Understand Reprogramming Events in the Donor Nuclei Following Somatic Cell Nuclear Transfer  
RS1-00389-1 Adhesion Molecule Function in Human Hematopoietic Development  
RS1-00392-1 Stress response signaling pathways in hESCs  
RS1-00394-1 Directed Vasculogenic and Cardiogenic Differentiation of Embryonic Stem Cells  
RS1-00395-1 Differentiation of Stem Cells into ‘Systems of Neurotransmitter' Phenotypes Related to Alzheimer’s and Huntington’s Diseases: Application of High Throughput Peptidomic Approaches with Mass Spectrometry  
RS1-00397-1 Proteome-wide Profiling of Ubiquitination and Sumoylation in Human Embryonic Stem Cells  
RS1-00398-1 Study of TBX3 Function in human Embryo Stem (hES) Cell Differentiation and Identification of Genome-Wide TBX3 Promoter Binding-Sites with the CHIP-GLAS Promoter Array  
RS1-00399-1 Characterizing and identifying hESCs and their derivatives by Raman imaging  
RS1-00400-1 ENGINEERED MANIPULATIONS OF HUMAN EMBRYONIC STEM CELLS USING NANO-NEEDLES AND NANO-PARTICLES  
RS1-00402-1 Down-Regulation of Alloreactive Immune Responses to hES Cell-Derived Graft Tissues 86
RS1-00403-1 Gene Targeting in Human ES Cells  
RS1-00404-1 Patient-specific cells with nuclear transfer 91
RS1-00405-1 Molecular Analysis of microRNAs in Pancreas Development  
RS1-00406-1 Assessment of the Immune Potential of Human Embryonic Stem Cells  
RS1-00407-1 Targeted Differentiation of Novel hESC Lines for Bladder Tissue Engineering Applications  
RS1-00408-1 Screening for Oncogenic Epigenetic Alterations in Human ES Cells 75
RS1-00409-1 Human Embryonic Stem Cells and Remyelination in a Viral Model of Demyelination 81
RS1-00411-1 The role of HER2 signaling in differentiation and maintenance of human embryonic stem cells 74
RS1-00412-1 Developmental Regulation of Human Embryonic Stem Cells by microRNAs  
RS1-00413-1 Using human embryonic stem cells to treat radiation-induced stem cell loss: Benefits vs cancer risk 77
RS1-00414-1 Treating Stress Urinary Incontinence with Human Embryonic Stem Cells  
RS1-00416-1 Production of Oocytes from Human ES Cells 83
RS1-00417-1 Derivation and Epigenomic Analysis of hES Cells  
RS1-00418-1 Stem cell therapy on hypertension: A potential source and role of nNOS in brainstem  
RS1-00419-1 3D_SpineTracker - Automated remyelination detection and classification of axons for sub-acutely injured spinal cord section images for temporal tracking of remyelination after stem cell treatment  
RS1-00420-1 Improving microenvironments to promote hematopoietic stem cell development from human embryonic stem cells 85
RS1-00421-1 Optimized hESC Cultures Using Microfluidics  
RS1-00422-1 Development of Blood and Liver Stem Cells from Embryonic Stem Cells  
RS1-00425-1 hESC mitochondrial transfer to empower withered cardiomyocytes  
RS1-00427-1 Human Embryonic Stem Cell Therapy for Retinal Degeneration  
RS1-00428-1 Sources of Genetic Instability in Human Embryonic Stem Cells. 80
RS1-00429-1 Treatment of Lung Disease with Inhaled Stem Cells  
RS1-00431-1 Differentiation of Human Embryonic Stem Cells to Heart Cells  
RS1-00432-1 Mitochondrial Dysfunction in Embryonic Stem Cells 93
RS1-00434-1 Transcriptional Regulation of Human Embryonic Stem Cells 92
RS1-00435-1 Derivation of New Human Embryonic Cell Lines in Full Compliance with Current FDA Regulatory Guidance  
RS1-00436-1 Fate and connectivity of HESCs in temporal lobe disorders.  
RS1-00439-1 Proteomics of the Oxidative Stress Response in Embryonic Stem Cells  
RS1-00440-1 Optimizing human embryonic stem cell-derived neural stem/progenitor cells for stroke cell therapy  
RS1-00441-1 Selecting Embryonic Cell-Derived Cardiomyocytes by Specific Surface Marker  
RS1-00442-1 Integrin ligation in human ESC (hESC) proliferation and fate determination  
RS1-00444-1 Role of the tumor suppressor gene, p16INK4a, in regulating stem cell phenotypes in embryonic stem cells and human epithelial cells. 84
RS1-00449-1 Force, Dimensionality and Stem Cell Fate 82
RS1-00450-1 Control of Herpes Simplex Virus latency by cellular DNA repair proteins  
RS1-00451-1 Development of a novel human embryonic stem cell (hESC) model of familial amyotrophic lateral sclerosis (ALS)  
RS1-00452-1 Induction of pluripotency in fibroblasts by fusion with enucleated human embryonic stem cell syncytia 80
RS1-00453-1 Hair Cells and Spiral Ganglion Neuron Differentiation from Human Embryonic Stem Cells 78
RS1-00455-1 Derivation and characterization of human ES cells from FSHD embryos 88
RS1-00457-1 Role of RXR in Nurr1-induced Differentiation of Human ES Cells and in Parkinson's Disease  
RS1-00458-1 Role of PK2 on the differentiation of human neural stem cells and ischemia-induced neurogenesis  
RS1-00461-1 MicroRNAs in Human Embryonic Stem Cell Self-Renewal and Differentiation  
RS1-00462-1 MicroRNAs in Human Stem Cell Differentiation and Mental Disorders 91
RS1-00463-1 Alternative splicing during neural differentiation of human embryonic stem cells.  
RS1-00464-1 hESCs for Articular Cartilage Regeneration 76
RS1-00465-1 A novel live study in a 3-D microfluidic model using multicolored quantum dot(QD) tagged probes: for imaging multiple protein(s) interactions whether activators/inhibitors or "bind / non-bind" using surface-enhanced Raman spectroscopy (SERS), multiphoton microscope (MPM) and Laser Tweezer.  
RS1-00466-1 Analysis of Candidate Neural Crest Cells Derived from Human ES Cells 91
RS1-00468-1 Genetic manipulation of human embryonic stem cells by lentiviral vectors.  
RS1-00469-1 Directed differentiation of hES cells into the heart valve lineage  
RS1-00470-1 Creating Human Embryonic Stem Cell Lines Containing Multiple Sclerosis Genomes via Cell Fusion  
RS1-00471-1 Effect of Tumor Necrosis Factor Alpha on Stem Cell Fate Determination in the Central Nervous System  
RS1-00472-1 Modulation of Stem Cell PTHrP/Wnt Signaling to Prevent Chronic Lung Disease  
RS1-00473-1 Regenerative CF Airway Epithelium by Embryonic Stem Cells  
RS1-00474-1 Pericellular proteolysis in human ES cell differentiation and tumorigenesis  
RS1-00477-1 Non-coding RNA as tool for the active control of stem cell differentiation 77
RS1-00480-1 Regulation of apoptosis during endocrine development